In 2021, Blair starred in Introducing, Selma Blair, a documentary about her life since being diagnosed with multiple sclerosis.
Her other notable film credits include Storytelling (2001), A Guy Thing (2003), A Dirty Shame (2004), The Fog (2005), WΔZ (2007), Feast of Love (2007), The Poker House (2008), Dark Horse (2011), Columbus Circle (2012), In Their Skin (2012), Ordinary World (2016), Mothers and Daughters (2016), Mom and Dad (2017), After (2019), and A Dark Foe (2020). She continued to find success with the comedies Legally Blonde (2001) and The Sweetest Thing (2002), and achieved international fame with her portrayal of Liz Sherman in the big-budget fantasy films Hellboy (2004) and Hellboy II: The Golden Army (2008). Her breakthrough came when she starred as Zoe Bean on the WB sitcom Zoe, Duncan, Jack and Jane (1999–2000), and as Cecile Caldwell in the cult film Cruel Intentions (1999).
She played a number of roles in films and on television before obtaining recognition for her leading role in the film Brown's Requiem (1998). Selma Blair Beitner (born June 23, 1972) is an American actress and author.
